Burkholderia pseudomallei Clinical Isolates Are Highly Susceptible <i>In Vitro</i> to Cefiderocol, a Siderophore Cephalosporin

Cefiderocol is a cephalosporin designed to treat multidrug-resistant Gram-negative infections. By forming chelated complex with ferric iron, cefiderocol transported into the periplasmic space via bacterial iron transport systems and primarily binds penicillin-binding protein 3 (PBP3) inhibit peptidoglycan synthesis. This mode of action results in having greater vitro activity against many bacilli than currently used carbapenems, ?-lactam/?-lactamase inhibitor combinations, cephalosporins.